Far away in the East both the Firstborn, (the Elves), and the Secondborn (or: Afterborn) Children of Ilúvatar, (Men), had awakened.
From their place of awakening, Cuiviénen, the Elves traveled to the West on request and urging of the Valar. Part of the Elves left Middle-earth for Valinor, while another, larger, part stayed in Middle-earth.
The first Men to arrive from the East were the Edain, friends of the Elves of Beleriand. In later times, from the East came the Wild Men who were in service of Morgoth and Sauron.