The Took clan was the most famous Hobbit family. ("Took" pronounced like "Two-k", not like "book" or "took" as in the past tense of "taken")
The first recorded Took (Tûk of unknown meaning in Hobbitish Westron) was an Isumbras Took, who became the 13th Thain of the Shire after Gorhendad Oldbuck crossed into Buckland, becoming Master there.
After Isumbras, the Thain position became hereditary in the Took family, and at the end of the Third Age his descendant Peregrin "Pippin" Took became the 19th Thain of the Took line, the 32nd in the Shire.
The Tooks lived in the Great Smials of Tuckborough, ruling Tookland in the Westfarthing of the Shire. A smaller clan called the North-Tooks lived far up in the Northfarthing; these were descendants of the legendary hero Bullroarer Took.
Tooks were mainly of Fallohide Hobbit stock, and were more adventurous than the other Hobbits. They also had quite a reputation for unusual behavior, a quality not exactly valued by most hobbits. For this reason they were seen as less respectable, and for the same reason they were one of the richer clans. The Wizard Gandalf was a known, if disreputable, associate. Bilbo Baggins and Meriadoc Brandybuck both had Took mothers.